POSTDOCTORAL RESEARCH ASSISTANT IN CELL BIOLOGY | EMBRC

POSTDOCTORAL RESEARCH ASSISTANT IN CELL BIOLOGY

2015.10.23

POSTDOCTORAL RESEARCH ASSISTANT IN CELL BIOLOGY

**CLOSED** The role of ciliary calcium signalling in the regulation of intraflagellar transport

The Marine Biological Association (MBA), Plymouth
Postdoctoral Research Assistant in Cell Biology
£26,274-29,552.
The role of ciliary calcium signalling in the regulation of intraflagellar transport

A 3-year BBSRC-funded postdoctoral position is available to study calcium signalling within eukaryote cilia using the model alga Chlamydomonas. Cilia and flagella (which represent different names for the same organelle) play essential roles in many eukaryotes and defects in human cilia are associated with many genetic disorders. Ca2+ is central to cilia and flagella function, regulating both the motile and the sensory roles of this organelle, although the precise roles of flagella Ca2+ signals are not fully understood. We have recently identified that flagella Ca2+ elevations regulate the process of intraflagellar transport (IFT) in Chlamydomonas (Collingridge et al, 2013, Current Biology, 23(22):2311-8). IFT is essential for the transport of component proteins during the assembly and maintenance of cilia and flagella, but also plays a critical role in key ciliary signalling pathways. The project will examine how flagellar Ca2+ signals in Chlamydomonas act to influence IFT using high resolution imaging techniques (TIRF microscopy) in combination with a range of molecular and biochemical approaches (e.g. RNAi gene knockdown, fluorescent protein tags, proteomics).

The molecular cell biology group at the MBA has an excellent track record in the characterization of novel signalling and membrane transport processes in plants and algae. The PDRA will work alongside a vibrant international research group with expertise in live cell imaging, electrophysiology and molecular cell biology and will work closely with collaborators both within the UK (Nottingham) and internationally (Munster, Germany). The MBA has excellent facilities for all aspects of cell biology research, including a dedicated BioImaging and electrophysiological facility and a fully equipped molecular suite. This position requires a highly motivated post-doctoral researcher with a track record in innovative research. A background in signal transduction/cell biology is desirable. Informal enquiries may be made to Dr Glen Wheeler (glw@mba.ac.uk). Further information may be obtained from www.mba.ac.uk/fellows/gwheeler.

Applicants for the PDRA position should send a specific cover letter and a detailed curriculum vitae describing research achievements and experience, along with the names and contact details of two referees to hr@mba.ac.uk (marked BBSRC/ GW).

For further details on this vacancy and essential information on how to apply, visit our Job Vacancies page at http://www.mba.ac.uk/category/vacancies/

Closing date: 23 November 2015

Nicolas, Pade | MBA

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